Why cancer rehabilitation matters

Impairments that may be relatively easy to address early, such as weakness, fatigue, neuropathy, pain, and reduced mobility, can become far more difficult and costly to treat if left unmanaged for weeks, months, or years. Rehabilitation is key to preventing long-term disability and maximising recovery.

For many people affected by cancer, the side effects of treatment can make physical activity feel too hard or even unsafe. This is where oncology physiotherapists play a critical role.

By safely prescribing and adapting exercise around these side effects, oncology physios help people achieve the therapeutic “dose” of exercise that research shows is required to improve survival, reduce recurrence, manage side effects, and optimise recovery.

Research consistently shows that cancer rehabilitation can:

  • Improve tolerance to chemotherapy and radiation
  • Reduce cancer-related fatigue
  • Alleviate peripheral neuropathies
  • Improve pain management
  • Support psychological wellbeing
  • Improve physical strength, mobility and stamina
  • Help individuals maintain independence and return to work, family roles and social life

A growing body of evidence shows that exercise not only improves wellbeing, but can also significantly impact cancer outcomes.

Systematic review results from over 100 studies show

  • Exercise after a cancer diagnosis can reduce cancer-related death by up to 44%.
  • Exercise may reduce the risk of cancer recurrence by up to 35%.
  • Exercise is the number one treatment for managing common and debilitating side effects of cancer treatment.
  • Emerging research suggests that exercising during treatment may improve chemotherapy effectiveness and completion rates. (NYT article & NEJM trial)

Colon cancer exercise trial (2025 NEJM study highlights):

  • 80% of patients who exercised remained cancer-free after 5 years, compared with 74% of non-exercisers (a 28% reduction in recurrence risk).
  • At 8 years post-treatment, 10% of the exercise group had died vs. 17% in the control group — a 37% lower risk of death.
  • Benefits may be linked to improvements in immune function, inflammation, hormone regulation, and better treatment tolerance.

"This trial has the potential to transform clinical practice."
— Caroline Geraghty, Cancer Research UK

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Breast Cancer and Exercise

Substantial progress has been made in the field of exercise-oncology research for breast cancer. Numerous studies now demonstrate that participation in physical activity is strongly associated with:

  • Reduced recurrence and mortality rates
  • Improved treatment tolerance and outcomes
  • Lower rates of side effects such as fatigue, weight gain, lymphedema, pain, neuropathy, and emotional distress

A comprehensive review published in Breast Cancer Research and Treatment (2024) highlights the importance of including exercise at all stages of care — prevention, treatment, and survivorship.

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"Exercise Oncology has come a long way — especially in breast cancer. Exercise is now recognised not only for prevention and survivorship but for improving treatment outcomes."

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Global umbrella review: exercise improves outcomes across many cancer types

The largest analysis of its kind (485 associations from 80 articles, published 2025) found:

  • Exercise reduces mortality, recurrence, fatigue, and depression across multiple cancer types.
  • High-certainty evidence exists for breast, prostate, colorectal and lung cancer survivors.
  • Pre-operative exercise improves recovery and hospital stay length for lung cancer patients.
  • Mind-body exercise also improves psychological and physical outcomes.

Conclusion: Exercise is safe, effective, and should be part of routine cancer care.

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Blood Cancer & Exercise

For people diagnosed with blood cancers such as leukaemia, lymphoma, and myeloma, exercise is becoming a vital part of care. Research shows that physical activity:

  • Reduces cancer-related fatigue, one of the most common side effects (Annals of Oncology)
  • Improves physical strength and stamina
  • Enhances mood, sleep, and quality of life
  • Supports treatment tolerance and immune system function

Exercise is increasingly being recommended during treatment and recovery for people with blood cancers, though programs should always be tailored and supervised by qualified professionals.

Emerging research in lung cancer

  • Exercise may serve as a vital adjunct to chemotherapy, radiation and surgery in lung cancer treatment.
  • Exercise reduces hospital stay, improves physical fitness, and may reduce complications.
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Fast-tracking recovery: why early intervention matters

  • The sooner rehabilitation starts, the faster patients rebuild strength, confidence and resilience. Early rehab reduces complications, lowers hospital readmissions, improves treatment tolerance and supports return to normal life.
  • One of the key reasons early intervention is so effective is that it helps prevent loss of muscle mass.
The Importance of Muscle Mass in Cancer Recovery

Recent research has underscored the critical role of muscle mass in both cancer treatment tolerance and long-term survival outcomes.

Low muscle mass (sarcopenia) is now recognised as a strong prognostic factor for overall mortality and cancer-specific survival — particularly in cancers such as breast, prostate, and gastrointestinal cancers.

Patients with low muscle mass are more likely to experience severe treatment side effects, require chemotherapy dose reductions, and face poorer overall recovery outcomes.

Importantly, growing evidence shows that low muscle mass poses a greater risk to health and survival than high fat mass in many people living with cancer. Prioritising muscle preservation and rebuilding during and after cancer treatment has therefore become a core focus of cancer rehabilitation.

Exercise, including progressive resistance training, plays a critical role in improving muscle mass, physical function, and treatment tolerance. This highlights the need for targeted, professionally supervised rehabilitation programs that focus on strength development alongside safe aerobic conditioning.

Related research

Recommended exercise guidelines

  • 150 minutes of moderate physical activity per week
  • 2 to 3 resistance training sessions per week
  • Exercise should be individually prescribed and progressed by qualified cancer rehab professionals.
  • The goal is safe, supervised, energising activity — not exhaustion.